منابع مشابه
Translational Antidote Research: A Bedside to Bench Tale
Although antidote development should proceed in an orderly fashion from observation, to experimental and safety studies, to clinical trials, this sequence is not always precisely followed. The development of fomepizole as an antidote for toxic alcohol and glycol poisoning is an example of how this may not be the case. Interest in the development of fomepizole was spurred in the 1960s. Shortly t...
متن کاملTranslational Research
Treatment of dominantly inherited muscle disorders remains a difficult task considering the need to eliminate the pathogenic gene product in a body-wide fashion. We show here that it is possible to reverse dominant muscle disease in a mouse model of facioscapulohumeral muscular dystrophy (FSHD). FSHD is a common form of muscular dystrophy associated with a complex cascade of epigenetic events f...
متن کاملTranslational nephrology: what translational research is and a bird's-eye view on translational research in nephrology
The ultimate aim of biomedical research is to preserve health and improve patient outcomes. However, by a variety of measures, preservation of kidney health and patient outcomes in kidney disease are suboptimal. Severe acute kidney injury has been treated solely by renal replacement therapy for over 50 years and mortality still hovers at around 50%. Worldwide deaths from chronic kidney disease ...
متن کاملBasic and translational research
Weinblatt ME, Bingham CO, Mendelsohn AM, et al. Ann Rheum Dis (2012). doi:10.1136/annrheumdis-2012-201411 1 of 9 and anti-TNF-experienced4 patients with RA when administered monthly via subcutaneous injection. Intravenous administration of golimumab every 12 weeks (q12 weeks) was previously assessed in a phase 3 trial in patients with RA, with persistent disease despite MTX therapy.5 While the ...
متن کاملTranslational research in retinology
Clinical laboratories are strong, integral partners in personalized health care. Laboratory databases hold a vast amount of data on human phenotypes, genotypes, biomarkers, progression of disease, and response to therapy. These structured and unstructured free text data are critical for patient care and a resource for personalized medicine and translational research. Laboratory data are integra...
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ژورنال
عنوان ژورنال: Critical Care Medicine
سال: 2018
ISSN: 0090-3493
DOI: 10.1097/ccm.0000000000003033